The Exceptional Chronobiology Sleep Mask Refill

The Exceptional Chronobiology Sleep Mask Refill is a high-performance treatment that is carefully synchronised to work in synergy with the skin’s natural overnight biorhythm of regeneration and self-repair processes, for a skin transformation overnight.


Out of stock

The Exceptional Chronobiology Sleep Mask



Noble Panacea offers the Exceptional Chronobiology Sleep Mask Refill. Packed with five different botanical oils, this overnight treatment delivers a spa-like experience. Additionally, this overnight face mask improves skin barrier function, balances sebum production, and decreases TEWL (trans-epidermal water loss).

Harnessing the power of OSMV technology, the Exceptional Chronobiology Sleep Mask Refill accurately delivers active ingredients to the skin throughout its overnight circadian rhythm process. As a result, the skin's natural reparative, regeneration, and detoxification processes enhance. Furthermore, OSMV also protects active ingredients, as well as delivering them with an extended-release method throughout. This ensures freshness of the ingredients and a continual dosage.

During the night, active ingredients are delivered in three distinct stages throughout your sleep cycle so you can awaken with visibly plump and youthful skin.

Stages of Skin Transformation

Stage 1: Detox

This occurs from 11 pm-4 am. During this time, the skin eliminates toxins. PHA and pre, pro, and post biotics work to reset and detoxify the skin.

Stage 2: Repair

The repair process takes place from 2 am-4 am. This is when cell growth and repair is at its peak. During this stage, retinol and peptides revive and rejuvenate the skin.

Stage 3: Nourish

This takes place from 4 am onwards, when the skin has maximum absorption. 2D hyaluronic acid and ceramide NP work to nourish the skin while also delivering protection and illumination.

To summarise, this remarkable treatment is the perfect addition to your skincare routine so that you can awaken with revitalised, younger looking skin.

Exceptional Chronobiology Sleep Mask Refill Clinical Results

After 4 weeks:

100% reported that their skin looked healthier, replenished, and energised
97% said that their skin felt firmer and more plumped
94% agreed that their stressed skin had calmed, with a visible reduction in redness and irritation.

After 8 weeks:

97% agreed that their skin appeared more luminous and radiant
91% saw dark spots and pigmentation diminish and lighten
89% felt that their deep wrinkles had improved in appearance

Please note this product is a refill for The Exceptional Chronobiology Sleep Mask.

The Exceptional Chronobiology Sleep Mask uses Noble Panacea's groundbreaking OSMV technology. Furthermore, it provides a results-driven treatment tailored to the skin's circadian rhythms.

Firstly, the mask is calibrated to release active ingredients at different times throughout your sleep to complement the skin's natural detox, repair, and absorption processes. Additionally, the treatment features antioxidants, hyaluronic acid, ceramides, retinol, PHAs, pre pro and post-biotics, vitamin C and bakuchiol. What's more, all of these powerful ingredients help to fight skin aging, uneven skin tone and texture, and restore luminosity.

After an 8 week study with 35 women:

  • 97% said skin looked luminous and radiant
  • 91% said dark spots and pigmentation appear diminished and lightened
  • 89% felt the appearance of deep wrinkles had improved

Noble Panacea is a science-led skincare company that offers a range of state-of-the-art skincare products for targeted solutions. Founded by scientist and Noble Laureate Sir Fraser Stoddart, the brand crafts its products to 'lift the spirits and empower people to embrace their most authentic natural beauty for a pure expression of self.'

Four decades of research alongside thousands of experiments led to the birth of OSMV (Organic Super Molecular Vessels). A single OSMV is 10,000 times smaller than a skin cell. OSMV technology is designed to deliver active ingredients with extreme precision and a delayed release into the precise location within a skin cell, allowing for ultimate timing, control, and sequence. This therefore enhances the perpetual potency of each treatment. Unlike regular skincare products that the skin completely absorbs instantly after application, OSMV continually delivers active ingredients to the skin during its 'therapeutic window'.

OSMV is an entirely unique delivery process, guaranteeing you optimum results.

The brand categorises its skincare products into 'The Brilliant', 'The Absolute', and 'The Exceptional'. Each targets different skin concerns, to protect, repair, and elevate your skin.

What's more, Noble Panacea values sustainability. Their Responsible Beauty value is a part of every aspect of the brand. From their production processes, clean formulations and sustainable packaging. Noble Panacea places clean skincare at the heart of their company.

With Noble Panacea, you can enhance your natural beauty while preventing and reducing skin aging. The brand delivers exceptionally high-quality skincare products with remarkable results. The Noble Panacea reviews speak for themselves!


Open the Active Dose with the Dose Opener and empty the mask onto the Gua Sha tool. Using the silicone brush applicator, apply the mask directly to your face, neck and eye area. Use the Gua Sha tool to sculpt your facial contours

Apply to cleansed skin 1-2 times weekly. Ensure you apply it as the last step of your skincare routine, just before sleeping.

Key Ingredients:

Organic Super Molecular Vessel Technology (OSMV): This unique patented delivery system protects and accurately delivers the formula's active ingredients for perpetual potency and maximum efficacy. It works in four steps. Firstly, OSMV provides ultimate protection – all ingredients are highly protected at their individual molecule level. This ensures freshness and prevents cross contamination. Secondly, OSMV releases active ingredients with extreme precision. Each ingredient is optimised to its unique profile to guarantee maximum absorption by the skin, and therefore increasing skin penetration by over 200%. Thirdly, individual ingredients are delivered in a programmed sequence to maximise their potency. Finally, OSMV delivers ingredients through an extended-release method (based on the ingredient and its benefits). This allows a continual dosage during the healing stage, when it is most powerful and effective. What's more, OSMV technology increases product penetration and therefore enhances the benefits of other ingredients.

Prebiotics, Probiotics, Postbiotics: This combination of Biotics work to support the skin's natural microbiome.

Gluconolactone: This PHA (Polyhydroxy Acid) has anti-aging benefits such as reducing wrinkles and increasing skin thickness. As well as this, it helps to remove dead skin cells and has antioxidant properties.

Glycolic Acid: This AHA (Alpha Hydroxy Acid) is a remarkable exfoliator. Glycolic acid benefits include being able to deeply penetrate the epidermis to encourage cellular activity and reduce the appearance of wrinkles.

Lactic Acid: This ingredient is an AHA that increases cell turnover. Lactic acid benefits the skin by improving firmness and minimising fine lines and wrinkles.

Retinol: This powerhouse ingredient has exceptional anti-aging properties. Retinol reduces fine lines and wrinkles by increasing collagen production. Additional retinol skin benefits include fading age spots, unblocking pores, and softening the skin.

Bakuchiol: This skincare ingredient shares similar properties with retinol. Bakuchiol skin benefits include improving brightness, balancing skin tone, wrinkle reduction, and increasing firmness.

Vitamin C: Multiple forms of vitamin C, ascorbyl palmitate, ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate, and ascorbyl glucoside, feature in The Exceptional Chronobiology Sleep Mask. Vitamin C skin benefits include stimulating collagen, brightening the complexion, and preventing premature aging.

Peptides: A collection of peptides feature in The Exceptional Chronobiology Sleep Mask. This includes acetyl hexapeptide-8 (argireline), palmitoyl tripeptide-38, sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11 and sh-Polypeptide-9. Peptides are naturally occurring in the skin; however, they often feature in skincare products due to their soothing, anti-aging, and anti-inflammatory properties. Peptides improve the skin barrier, clear breakouts, calm inflammation, and enhance elasticity.

Ceramide NP: This ceramide helps to retain the skin's moisture balance. Furthermore, it supports the natural lipid barrier of aging skin. Ceramides' skin benefits include promoting a healthy skin barrier, preventing dryness and irritation, and marinating a firm and plump appearance.

2D Hyaluronic acid: Hydrolysed sodium hyaluronate and sodium hyaluronate are included in the Chronobiology Sleep Mask. Hydrolysed Sodium Hyaluronate is a low-molecular-weight hyaluronic acid. It works to reduce wrinkles and enhance skin elasticity. Sodium Hyaluronate is also low-molecular-weight. It is effective at distributing hydration evenly throughout the skin.

Niacinamide: This ingredient has an abundance of skin benefits. This includes boosting collagen, reducing sebum production, and minimising the appearance of pores.

Coenzyme Q10: This compound is naturally present in the skin and acts as a powerful antioxidant. Therefore, it protects the skin from oxidative damage and prevents premature skin aging.


Water/Eau/Aqua, Argania Spinosa (Argan) Kernel Oil, Glycerin, Oligosaccharide Fatty Acid Esters (OSMV), Squalane, Ascorbyl Glucoside, Lactobacillus Ferment, Sucrose Stearate, Cetearyl Alcohol, Niacinamide, Potassium Cetyl Phosphate, Vitis Vinifera (Grape) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Dipalmitoyl Hydroxyproline, Alpha-Glucan Oligosaccharide, Propanediol, Rosa Damascena (Rose) Flower Water, Aloe Barbadensis Leaf Juice, Butyrospermum Parkii (Shea) Butter, Jojoba Esters, Stearyl Alcohol, Lactic Acid, Opuntia Ficus-Indica (Prickly Pear) Seed Oil, Nigella Sativa (Black Cumin) Seed Oil, Ceramide NP, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Retinol, Gluconolactone, Persea Gratissima (Avocado) Oil, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-38, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-11, sh-Polypeptide-9, Centella Asiatica (Gotu Kola) Leaf Extract, Magnesium Ascorbyl Phosphate, Glycolic Acid, Camellia Sinensis (Green Tea) Leaf Extract, Bakuchiol, Caffeine (Coffea Arabica), Panax Ginseng Root Extract, Acetyl Glutamine, Lecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Allantoin, Xanthan Gum, Carnitine, Rice Amino Acids, Vitis Vinifera (Grape) Seed Extract, Ascorbyl Tetraisopalmitate, Glyceryl Linoleate, Phytic Acid, Ascorbyl Palmitate, Panthenol, Tocopherol, Tocopheryl Acetate, Glyceryl Linolenate, Oryza Sativa (Rice) Bran Extract, Helianthus Annuus (Sunflower) Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Ubiquinone, Potassium Hydroxide, Phospholipids, Bacillus/Folic Acid Ferment Filtrate Extract, Hydroxypropyl Cyclodextrin, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Benzoate.

Free from: Phthalates, parabens, silicone, mineral oil GMO's, SLS & SLES, alcohol, artificial fragrance, nitrates, palm oil, petrolatum, artificial colours, and gluten

Non-comedogenic & dermatologist-approved.

Vegan & cruelty-free.

you may also like


There are no reviews yet.

Be the first to review “The Exceptional Chronobiology Sleep Mask Refill”

Your email address will not be published. Required fields are marked *


Our scientists are constanty in search of the newest breakthroughs in skincare which you can read all about on our blog.

12 Best Facial Cleanser for Men for all skin types

March 3, 2023

14 Best Facial Cleansers for all skin types 2023

March 3, 2023

What Are ZENii Supplements?

November 8, 2022

The Game-changing Skincare Ingredient: Niacinamide

November 3, 2022

MZ Skin Brighten & Perfect: Your Solution for Brighter Skin

November 1, 2022

The Ideal Morning Skincare Routine For Dry Skin

October 27, 2022

Dehydrated Acne Prone Skin: The Only Guide You Need

October 25, 2022

Calecim Review: What Is Stem Cell Skincare?

October 20, 2022

Heliocare Review: All Your Questions Answered

October 18, 2022

Skinade Clear: Your 30 Day Clear Skin Treatment

October 13, 2022

Dermaceutic Review: Expertly Formulated Skincare For You

October 11, 2022

What’s the Best Acne Scar Treatment?

October 6, 2022

Is Indeed Labs Nanoblur Worth the Hype?

October 4, 2022

RevitaLash UK: The Eyelash Serum Taking The World By Storm

September 29, 2022

Managing Menopause Skin Changes

September 27, 2022

10 Skincare Tips to Beat Holiday Heat

September 22, 2022

Noble Panacea Review: All Your Questions Answered

September 20, 2022

Discover Your Dream Skincare Routine With Osmosis MD Skincare

September 15, 2022

Cellulite on Legs: The Best Way to Clear It for Good!

September 13, 2022

Introducing The Revolutionary Evenswiss UK Range

September 8, 2022

The Best Vegan Skincare UK

September 6, 2022

What Is Liposomal Vitamin C and Why Is It Amazing?

September 1, 2022

Dermoi Heads To British Beauty Week

August 30, 2022

Can You Restore Skin Elasticity?

August 25, 2022

The Skincare Routine Order You Should Stick To

August 23, 2022

All You Need to Know About Skinade Collagen

August 19, 2022

Is Jane Iredale a Good Makeup Brand? 

August 16, 2022

Why You Should Avoid Fake Tan

August 12, 2022

Which Stretch Marks Cream Is Best?

August 9, 2022

The Top 6 Benefits of Sunscreen

August 5, 2022

What Are The Best Skincare Products for Summer?

August 2, 2022

The 10 Best Tips For a Summer Skin Glow

July 29, 2022

The Brilliant Benefits of Liposomal Delivery for Supplements

April 25, 2022

The Perfect Skincare Diet: Which Foods Are Important for Healthy Skin?

April 24, 2022

Opatra Dermisonic Is the Best-Selling Number 1 Anti-Aging Device

April 22, 2022

Celebrity Chemical Peels: Facial Peels From the Red Carpet

April 15, 2022

The Best Collagen Drink: Victoria Beckham's Anti-Aging Secret

March 20, 2022

Why You Need To Try Osmosis Beauty Supplements

March 15, 2022

The Best Hyperpigmentation and Dark Spots Treatments

March 9, 2022

Anti-aging: Does Good Gut Health Transform Your Skin?

March 8, 2022

Anti-Aging Endocare: The Revolutionary Skincare Brand

March 7, 2022

Why Your Skin Pigmentation Is Getting Worse

March 6, 2022

Skin Thinning: Why Is Your Skin Losing Thickness?

March 5, 2022

The 14 Biggest & Most Ridiculous Skincare Myths

March 2, 2022

PCA Skin: A History of Their Achievements in Skincare

February 28, 2022

5 Pieces of Facial Aftercare Advice That Will Save Your Skin

February 25, 2022

Pregnancy Acne: What’s the Best and Safest Treatment?

February 23, 2022

The Difference Between Squalane and Squalene in Skincare

February 21, 2022

The Best Active Ingredients for Sensitive Skin

February 20, 2022

Which Collagen Supplement Is Best?

February 18, 2022

What are the Skincare Breakthroughs & Trends

February 17, 2022

How Fillerina Treats Wrinkles & Aging Differently

February 15, 2022

The Benefits of Micelle Delivery for Supplements

February 15, 2022

Hormonal Acne Treatment That No One Tells You About

February 14, 2022

How Long Does It Take for a Skincare Routine to Show Results?

February 13, 2022

Should You Avoid Retinol After a Facial Treatment?

February 13, 2022

Introducing The Revolutionary Skincare Brand Altrient UK

February 11, 2022

Emepelle: The Best Anti-Aging Skincare for Menopause

February 10, 2022

What Are the Best Acne Facial Treatments to Remove Acne Scars?

February 9, 2022

Beauty Tech startup in London: When Science Marries Skincare

February 7, 2022

How to Get Rid of Acne Scars

February 7, 2022

5 Treatments That Damage Your Skin

February 5, 2022

RevitaLash Cosmetics: Meet Meghan Markle’s Go-To Lash Serum

February 4, 2022

Sunscreen for Dark Skin: Sunscreens That Don’t Leave a White Cast

February 3, 2022

Can You Use Retinol if You Have Sensitive Skin? Dermatologist Advice

February 1, 2022

Why Your Rosacea Is Getting Worse

January 31, 2022

Why Medium and Deep Chemical Peels Damage Your Skin

January 30, 2022

Why Microdermabrasion Damages Your Skin

January 29, 2022

Does the Skinade Collagen Drink Really Work?

January 28, 2022

Osmosis Skincare: Does it Treat Acne Differently?

January 27, 2022

Endocare Anti-Aging Skincare is the Future - Here's Why!

January 26, 2022

The Pros & Cons of Chemical Peels: Are They Worth It?

January 25, 2022

My Acne Journey: Melody’s Acne Story

January 21, 2022

Cruelty Free Skincare Products and Vegan Skincare Brands

January 21, 2022

Collagen Drink Benefits: How Are They So Effective?

January 20, 2022

My Hormonal Acne Journey: How I Cleared My Skin

January 19, 2022

What Is DIM and How Does It Help With Hormonal Acne?

January 18, 2022

MEP Technology: A Breakthrough Innovation for Anti-Aging Skincare

January 17, 2022

Rosacea Treatments: Which Ingredients Show Real Results?

January 16, 2022

Is Oily Skin a Sign of Poor Gut Health?

January 14, 2022

Oily Skin and Gut Health: How Can Gut Health Affect Your Skin and Why?

January 13, 2022

How Dermaplaning Is Damaging Your Skin

January 12, 2022

Skin Accumax: Miracle Acne Treatment or Not?

January 11, 2022

All You Need to Know About Acne Treatment Skin Clear Biome

January 10, 2022

Red Skin and Gut Health: Does Gut Health Affect Rosacea?

January 9, 2022

Why You Should Never Try Dermaplaning, Chemical Peels Are a Safer Choice!

January 8, 2022

Treating Acne: Accutane Side Effects

January 7, 2022

The Top 20 Most Asked Skincare Questions: Everything You Should Know!

January 6, 2022

Combining Retinol and Sunbeds: What Are The Risks?

January 5, 2022

Anti-Aging Bakuchiol: A Pregnancy-Safe Alternative to Retinol

January 4, 2022

Why HydraFacial Treatments Are Bad

January 3, 2022

Can You Mix Two Serums Together? Learn How to Cocktail Your Serums Like a Pro!

January 2, 2022

Results I’ve Seen Since Taking a Probiotic for My Acne Skin

January 1, 2022