The Exceptional Chronobiology Sleep Mask Refill

The Exceptional Chronobiology Sleep Mask Refill is a high-performance treatment that is carefully synchronised to work in synergy with the skin’s natural overnight biorhythm of regeneration and self-repair processes, for a skin transformation overnight.


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Noble Panacea offers the Exceptional Chronobiology Sleep Mask Refill. Packed with five different botanical oils, this overnight treatment delivers a spa-like experience. Additionally, this overnight face mask improves skin barrier function, balances sebum production, and decreases TEWL (trans-epidermal water loss).

Harnessing the power of OSMV technology, the Exceptional Chronobiology Sleep Mask Refill accurately delivers active ingredients to the skin throughout its overnight circadian rhythm process. As a result, the skin's natural reparative, regeneration, and detoxification processes enhance. Furthermore, OSMV also protects active ingredients, as well as delivering them with an extended-release method throughout. This ensures freshness of the ingredients and a continual dosage.

During the night, active ingredients are delivered in three distinct stages throughout your sleep cycle so you can awaken with visibly plump and youthful skin.

Stages of Skin Transformation

Stage 1: Detox

This occurs from 11 pm-4 am. During this time, the skin eliminates toxins. PHA and pre, pro, and post biotics work to reset and detoxify the skin.

Stage 2: Repair

The repair process takes place from 2 am-4 am. This is when cell growth and repair is at its peak. During this stage, retinol and peptides revive and rejuvenate the skin.

Stage 3: Nourish

This takes place from 4 am onwards, when the skin has maximum absorption. 2D hyaluronic acid and ceramide NP work to nourish the skin while also delivering protection and illumination.

To summarise, this remarkable treatment is the perfect addition to your skincare routine so that you can awaken with revitalised, younger looking skin.

Exceptional Chronobiology Sleep Mask Refill Clinical Results

After 4 weeks:

100% reported that their skin looked healthier, replenished, and energised
97% said that their skin felt firmer and more plumped
94% agreed that their stressed skin had calmed, with a visible reduction in redness and irritation.

After 8 weeks:

97% agreed that their skin appeared more luminous and radiant
91% saw dark spots and pigmentation diminish and lighten
89% felt that their deep wrinkles had improved in appearance

Please note this product is a refill for The Exceptional Chronobiology Sleep Mask.

The Exceptional Chronobiology Sleep Mask uses Noble Panacea's groundbreaking OSMV technology. Furthermore, it provides a results-driven treatment tailored to the skin's circadian rhythms.

Firstly, the mask is calibrated to release active ingredients at different times throughout your sleep to complement the skin's natural detox, repair, and absorption processes. Additionally, the treatment features antioxidants, hyaluronic acid, ceramides, retinol, PHAs, pre pro and post-biotics, vitamin C and bakuchiol. What's more, all of these powerful ingredients help to fight skin aging, uneven skin tone and texture, and restore luminosity.

After an 8 week study with 35 women:

  • 97% said skin looked luminous and radiant
  • 91% said dark spots and pigmentation appear diminished and lightened
  • 89% felt the appearance of deep wrinkles had improved

Noble Panacea is a science-led skincare company that offers a range of state-of-the-art skincare products for targeted solutions. Founded by scientist and Noble Laureate Sir Fraser Stoddart, the brand crafts its products to 'lift the spirits and empower people to embrace their most authentic natural beauty for a pure expression of self.'

Four decades of research alongside thousands of experiments led to the birth of OSMV (Organic Super Molecular Vessels). A single OSMV is 10,000 times smaller than a skin cell. OSMV technology is designed to deliver active ingredients with extreme precision and a delayed release into the precise location within a skin cell, allowing for ultimate timing, control, and sequence. This therefore enhances the perpetual potency of each treatment. Unlike regular skincare products that the skin completely absorbs instantly after application, OSMV continually delivers active ingredients to the skin during its 'therapeutic window'.

OSMV is an entirely unique delivery process, guaranteeing you optimum results.

The brand categorises its skincare products into 'The Brilliant', 'The Absolute', and 'The Exceptional'. Each targets different skin concerns, to protect, repair, and elevate your skin.

What's more, Noble Panacea values sustainability. Their Responsible Beauty value is a part of every aspect of the brand. From their production processes, clean formulations and sustainable packaging. Noble Panacea places clean skincare at the heart of their company.

With Noble Panacea, you can enhance your natural beauty while preventing and reducing skin aging. The brand delivers exceptionally high-quality skincare products with remarkable results. The Noble Panacea reviews speak for themselves!


Open the Active Dose with the Dose Opener and empty the mask onto the Gua Sha tool. Using the silicone brush applicator, apply the mask directly to your face, neck and eye area. Use the Gua Sha tool to sculpt your facial contours

Apply to cleansed skin 1-2 times weekly. Ensure you apply it as the last step of your skincare routine, just before sleeping.

Key Ingredients:

Organic Super Molecular Vessel Technology (OSMV): This unique patented delivery system protects and accurately delivers the formula's active ingredients for perpetual potency and maximum efficacy. It works in four steps. Firstly, OSMV provides ultimate protection – all ingredients are highly protected at their individual molecule level. This ensures freshness and prevents cross contamination. Secondly, OSMV releases active ingredients with extreme precision. Each ingredient is optimised to its unique profile to guarantee maximum absorption by the skin, and therefore increasing skin penetration by over 200%. Thirdly, individual ingredients are delivered in a programmed sequence to maximise their potency. Finally, OSMV delivers ingredients through an extended-release method (based on the ingredient and its benefits). This allows a continual dosage during the healing stage, when it is most powerful and effective. What's more, OSMV technology increases product penetration and therefore enhances the benefits of other ingredients.

Prebiotics, Probiotics, Postbiotics: This combination of Biotics work to support the skin's natural microbiome.

Gluconolactone: This PHA (Polyhydroxy Acid) has anti-aging benefits such as reducing wrinkles and increasing skin thickness. As well as this, it helps to remove dead skin cells and has antioxidant properties.

Glycolic Acid: This AHA (Alpha Hydroxy Acid) is a remarkable exfoliator. Glycolic acid benefits include being able to deeply penetrate the epidermis to encourage cellular activity and reduce the appearance of wrinkles.

Lactic Acid: This ingredient is an AHA that increases cell turnover. Lactic acid benefits the skin by improving firmness and minimising fine lines and wrinkles.

Retinol: This powerhouse ingredient has exceptional anti-aging properties. Retinol reduces fine lines and wrinkles by increasing collagen production. Additional retinol skin benefits include fading age spots, unblocking pores, and softening the skin.

Bakuchiol: This skincare ingredient shares similar properties with retinol. Bakuchiol skin benefits include improving brightness, balancing skin tone, wrinkle reduction, and increasing firmness.

Vitamin C: Multiple forms of vitamin C, ascorbyl palmitate, ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate, and ascorbyl glucoside, feature in The Exceptional Chronobiology Sleep Mask. Vitamin C skin benefits include stimulating collagen, brightening the complexion, and preventing premature aging.

Peptides: A collection of peptides feature in The Exceptional Chronobiology Sleep Mask. This includes acetyl hexapeptide-8 (argireline), palmitoyl tripeptide-38, sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11 and sh-Polypeptide-9. Peptides are naturally occurring in the skin; however, they often feature in skincare products due to their soothing, anti-aging, and anti-inflammatory properties. Peptides improve the skin barrier, clear breakouts, calm inflammation, and enhance elasticity.

Ceramide NP: This ceramide helps to retain the skin's moisture balance. Furthermore, it supports the natural lipid barrier of aging skin. Ceramides' skin benefits include promoting a healthy skin barrier, preventing dryness and irritation, and marinating a firm and plump appearance.

2D Hyaluronic acid: Hydrolysed sodium hyaluronate and sodium hyaluronate are included in the Chronobiology Sleep Mask. Hydrolysed Sodium Hyaluronate is a low-molecular-weight hyaluronic acid. It works to reduce wrinkles and enhance skin elasticity. Sodium Hyaluronate is also low-molecular-weight. It is effective at distributing hydration evenly throughout the skin.

Niacinamide: This ingredient has an abundance of skin benefits. This includes boosting collagen, reducing sebum production, and minimising the appearance of pores.

Coenzyme Q10: This compound is naturally present in the skin and acts as a powerful antioxidant. Therefore, it protects the skin from oxidative damage and prevents premature skin aging.


Water/Eau/Aqua, Argania Spinosa (Argan) Kernel Oil, Glycerin, Oligosaccharide Fatty Acid Esters (OSMV), Squalane, Ascorbyl Glucoside, Lactobacillus Ferment, Sucrose Stearate, Cetearyl Alcohol, Niacinamide, Potassium Cetyl Phosphate, Vitis Vinifera (Grape) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Dipalmitoyl Hydroxyproline, Alpha-Glucan Oligosaccharide, Propanediol, Rosa Damascena (Rose) Flower Water, Aloe Barbadensis Leaf Juice, Butyrospermum Parkii (Shea) Butter, Jojoba Esters, Stearyl Alcohol, Lactic Acid, Opuntia Ficus-Indica (Prickly Pear) Seed Oil, Nigella Sativa (Black Cumin) Seed Oil, Ceramide NP, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Retinol, Gluconolactone, Persea Gratissima (Avocado) Oil, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-38, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-11, sh-Polypeptide-9, Centella Asiatica (Gotu Kola) Leaf Extract, Magnesium Ascorbyl Phosphate, Glycolic Acid, Camellia Sinensis (Green Tea) Leaf Extract, Bakuchiol, Caffeine (Coffea Arabica), Panax Ginseng Root Extract, Acetyl Glutamine, Lecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Allantoin, Xanthan Gum, Carnitine, Rice Amino Acids, Vitis Vinifera (Grape) Seed Extract, Ascorbyl Tetraisopalmitate, Glyceryl Linoleate, Phytic Acid, Ascorbyl Palmitate, Panthenol, Tocopherol, Tocopheryl Acetate, Glyceryl Linolenate, Oryza Sativa (Rice) Bran Extract, Helianthus Annuus (Sunflower) Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Ubiquinone, Potassium Hydroxide, Phospholipids, Bacillus/Folic Acid Ferment Filtrate Extract, Hydroxypropyl Cyclodextrin, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Benzoate.

Free from: Phthalates, parabens, silicone, mineral oil GMO's, SLS & SLES, alcohol, artificial fragrance, nitrates, palm oil, petrolatum, artificial colours, and gluten

Non-comedogenic & dermatologist-approved.

Vegan & cruelty-free.

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