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Alpha Arbutin

Alpha Arbutin

Why it's Dermoi

Alpha Arbutin is a skin lightening agent that is effective in managing hyperpigmentation. The molecule is synthesised from natural Arbutin but is 10x more effective. It acts by inhibiting the enzyme responsible to produce skin pigment called tyrosinase.

Some skin lightening agents, such as hydroquinone, are well known for their efficacy, but are associated with a range of unwanted side-effects. Alpha Arbutin is non-irritating and does not cause sun sensitivity.

Description

Alpha Arbutin is a lightening agent that is biosynthesized by microbial enzymes or microorganisms.¹ Interestingly, it is derived from naturally occurring Arbutin, but is much more efficient in inhibiting the tyrosinase activity.¹

Alpha Arbutin helps to manage hyperpigmentation in the skin. Hyperpigmentation is the result of changes to melanogenesis (production and distribution of skin pigment). This can be from an increase in melanocyte cells, melanosome production, melanin synthesis, and/or melanocyte hyperplasia (greater deposition of melanocytes within the skin).¹ All of these factors can increase the presence of melanin (skin pigments) in the skin.

The synthesis of melanin in the skin is under the control of an enzyme called tyrosinase.¹² Alpha inhibits the activity of the tyrosinase enzyme, thereby reducing the amount of melanin in the epidermis.¹² This brightens and lightens existing dark spots and prevents the formation of additional dark spots.

In cosmeceutical formulations, Alpha-Arbutin has the benefit of being highly stable, non-irritating and does not cause sun sensitivity.¹

References

1. Alpha Arbutin as a Skin Lightening Agent: A Review. International Journal of Pharmaceutical Research. 2021;13(02).
2. Saeedi M, Khezri K, Seyed Zakaryaei A, Mohammadamini H. A Comprehensive Review of the Therapeutic Potential of Arbutin. Phytotherapy Research. 2021;35(8):4136-4154.

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